Direct effects

Top Line: Does metastasis directed therapy alone delay the need for systemic therapy in patients with oligorecurrent prostate cancer?

The Study: The ORIOLE and STOMP trials evaluated the use of metastasis directed therapy (MDT) alone (no ADT) in patients with oligometastatic prostate cancer. This retrospective study from a Mayo Clinic registry of C-11 choline PET analyzed outcomes for patients oligorecurrent prostate cancer treated with MDT. Included patients had biochemical recurrence after prior radical prostatectomy or primary radiation and a solitary site of metastatic disease that was treated with surgery or SBRT MDT and no ADT. Despite this very narrow inclusion criteria, 124 patients were identified. Just over half (54%) had surgery, and most of those patients (91%) had lymph node disease. Median pre-MDT PSA was 2.2, which declined to 0.15 at 3 months. In contrast, most of the patients treated with SBRT had bone metastasis (94.7%). PSA kinetics are different after radiation, and the median PSA declined from 2.7 pre-MDT to 1.3 at 3 months. Among those who had surgery, median time to biochemical progression was 8.3 months, and the rate of 3-year bPFS was 17.9%. Median time to initiating systemic therapy was 18.5 months. In the SBRT group, median time to biochemical progression was 9.5 months, and the rate of 3-year bPFS was 12.3%. Median time to initiate systemic therapy was 17.8 months.

TBL: In this single center study, surgery was the primary form of MDT for lymph node oligorecurrences while SBRT was used for bone oligorecurrences. Both forms of MDT successfully delayed disease progression and initiation of systemic therapy. | Andrews, J Urol 2022


  1. 🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭🔭
    My Name is Pedro from the United States, I want to say thank you to Mr Mark Toray for the good thing he has done for me, Though am not sure if this is the best forum to show my joy and happiness for what he has done for me but I can’t hide my happiness and my joy so I have to share it with people. This is unbelievable, at first I never actually built any interest in this Binary/Forex trading of a thing but when I later gave it a try with the Help of this wonderful Expert Trader Mr Mark Toray, it was a successful trade for me. All I did was to invest $1000 into my first trading and to my greatest surprise, I received a huge amount of $12,520 as profit in 7 days of trading… Mr Mark Toray was the trader that made it possible and he is still doing it all for me.. You want to be happy and be free like me do well to reach out to her via Email: or Telegram: @Mark4toray_fx


Post a Comment

Popular Posts