A new PARADIGM.
The Japanese phase 3 PARADIGM trial analyzed 802 patients with metastatic chemo-naive RAS-wild type colon cancer receiving mFOLFOX randomized to the addition of either the EGFR-inhibitor panitumumab or the more standard VEGF-inhibitor bevacizumab. Well, it made the plenary session because it met its primary endpoint of with median overall survival times of 34 months with standard bev versus 39 months with the novel panitumumab. A pre-planned analysis demonstrated this benefit was exclusively seen among the majority with left-sided primary tumors (n=604). | Yoshino, ASCO 2022