Third time’s a harm?

While it is clear a third dose of an mRNA vaccine can significantly minimize risk of both symptomatic and asymptomatic SARS-CoV-2 infection—a relative reduction of 93% was reported in this well-done study on 1928 vaccinated healthcare workers in Israel in the time of Delta—the decreased pathogenicity of the current Omicron variant makes the calculus on third doses for adolescents and young adults more difficult than ever. | Spitzer, JAMA 2022 & Gutman, Atlantic 2022

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