The big picture.

Top Line: Does adjuvant radiation improve disease-free survival in patients with resected, N2 non-small cell lung cancer?

The Study: You probably already know about the results of the LungART trial. Here we have its final publication, which is a good opportunity to delve into the details and consider the trial’s meaning for post-op radiation therapy (PORT). LungART was a randomized, phase 3 European trial of 501 patients with completely resected NSCLC and N2 nodal involvement. Ninety-one percent were staged with PET/CT. They were randomized to receive PORT or no PORT. Almost all patients (96%) received chemotherapy with most receiving adjuvant chemo (75-78%). PORT followed adjuvant chemo. The radiation dose was 54 Gy in either 27 or 30 fractions. The CTV included involved nodal stations with an additional 1 cm CTV margin for microscopic disease, the ipsilateral hilum, the bronchial stump, and stations 4 (lower paratracheal) and 7 (subcarinal). Most patients were treated with 3D conformal (89%) with 11% receiving IMRT. Median mean heart dose was 13.4 Gy (11.7 Gy right-sided tumors, 17 Gy left-sided tumors), and median heart V35 was 15%. Median lung V20 was 23%. At 3-years, PORT did not improve the rate of DFS (47% v 44%). Median DFS 30.5 v 22.8 months. The story is in the breakdown of DFS events, which occurred in 57% with PORT and 61% without. The rate of relapse or metastasis was lower after PORT (49% v 58%), which was driven by a significant reduction in the rate of mediastinal relapse (14% v 28%). However, the reduction in mediastinal relapse did not affect the rates of brain metastasis (13.5% v 11%) or extracranial metastasis (28% v 29%). And while fewer patients died of disease recurrence after PORT (27% v 35%), there was a higher rate of cardiopulmonary death (6% v <1%). As a result, there was no difference in 3-year overall survival (67% v 69%). 

TBL: Despite reducing mediastinal relapse, PORT does not significantly improve disease-free or overall survival for patients with resected N2 NSCLC. | Le Pechoux, Lancet Oncol 2021

Comments

  1. It Tears me Up Whenever we receive complaints from Clients About Their Experience With the Hackers They Met Before They Heard about us.
    These Days There Are alot of Hackers Online, You Just Have to Be Careful about who you meet for help, because many people now don't know who to ask for help anymore but there's actually a solution to that which I am giving you for free, Don't go out there seeking for Hackers Yourself, Because the probability of getting a Real Hacker Out there Is Very Slim . ❌❌ ❌ Most Of Them are actually not who they say they're, they are just here to Rip people Off, You Can Always Identify Them With Their False Advertisements and False Testimonies Trying To Lure you Into their Arms, And most of them use yahoomails, gmails and other cheaper email providers which could easily expose their vulnerabilities, Please Don’t Fall For Them�� Come To Think Of It, Why would a Legit Hacker Be using a gmail or a cheap email provider that exposes his vulnerabilities????⚠️⚠️⚠️
    Well, Our Purpose Here Is To Link You Up With Top Legit Hackers With Great Online Reputations and Impressive LinkedIn Profiles That’ll Blow Your Mind.

    ☑️ COMPOSITE FIRMWARE SECURITY SPECIALISTS is here to Provide you with The Best Hackers, So you can get saved from The Arms of the Fake Hackers❌❌.


    ☑️All our Specialists are well experienced in their various niches with Great Skills, Technical Hacking Strategies And Positive Online Reputations And Recommendations��
    They hail from a proven track record and have cracked even the toughest of barriers to intrude and capture all relevant data needed by our Clients.

    We have Digital Forensic Specialists, Certified Ethical Hackers, Software Engineers, Firmware Security Experts, Private investigators and more. Our Goal is to make your digital life secure, safe and hassle free by Linking you Up With these great Professionals such as JACK CABLE, ARNE SWINNEN, SEAN MELIA, DAWID CZAGAN, BEN SADEGHIPOUR And More. These Professionals are Well Reserved Professionals who are always ready to Handle your job with great energy and swift response so that your problems can be solved very quickly.
    All You Need to Do is to send us a mail and we’ll Assign any of these specialists to Handle your Job immediately.

    ☑️ Below Is A Full List Of Our Services:
    ▪️ FUNDS RECOVERY ON SCAM INVESTMENTS, BINARY OPTIONS TRADING and ALL TYPES OF SCAMS.
    ▪️ WEBSITE AND DATABASE HACKING ��
    ▪️ CREDIT REPAIR. ��
    ▪️ PHONE HACKING & CLONING (giving you �� Unnoticeable access to everything Happening on the Target’s Phone)
    ▪️ CLEARING OF CRIMINAL RECORDS ❌
    ▪️ SOCIAL MEDIA ACCOUNTS HACKING ��
    ▪️RECOVERY OF DELETED FILES ��
    ▪️LOCATION TRACKING ��
    ▪️BITCOIN MINING ⛏ And lot More.


    ☑️ CONTACT:
    .....
    firmwarehacks@gmail.com
    ��2021 © composite firmware specialists
    ��Want faster service? Contact us!
    ��All Rights Reserved ®️

    ReplyDelete

Post a Comment

Popular Posts