Seeing signs

Top Line: What imaging features are predictive of local recurrence after lung SBRT?

The Study: It can be challenging to differentiate treatment effects from early tumor recurrence with both CT and PET/CT following SBRT. Here’s a review of 32 studies analyzing CT and PET/CT features predictive of local recurrence (LR) after SBRT for early stage NSCLC. The rate of recurrence across studies was 13%. Among CT high risk features, the three strongest predictors of LR were craniocaudal growth, bulging margin, and enlarging opacity ≥ 12 months after treatment–the latter being the best single CT predictor of LR. In addition, the development of multiple risk features had a high sensitivity and specificity for LR. For instance, the presence of both bulging margin and craniocaudal growth had an 85% sensitivity and 100% specificity. CT kinetics > 12 months were also predictive, including 3 consecutive rises in size/volume. In the first 12 months after SBRT, a PET feature suspicious for LR was a <5% decrease in SUVmax from pretreatment SUVmax. After 12 months, a SUVmax > 5 or a SUVmax > 4.5 along with a mass-like shape of uptake were suspicious of LR. An important point is that radiographic features suggestive of recurrence really don’t become useful until 6 months and perform best > 12 months after treatment. The study ends with a very nice algorithm for working through post-SBRT imaging to identify local recurrence.

TBL: CT and PET/CT features are helpful in identifying local recurrence after SBRT for NSCLC with most features performing better > 12 months after treatment. | Lee, Int J Radiat Oncol Biol Phys 2021

Comments

  1. I'm 61 years old.  I contracted hpv in 2011' I has be taking lot treatment for it and embarrassed some months ago the wart stated coming out seriously, I used lot recommendation because there was lot warts around my anus and was so . but today I'm totally happy I got the virus eliminated by using natural treatment from Dr Onokun herbal center after his treatment I got cured. all the warts went away' seriously believed Dr. Onokun he have the cure for human papillomavirus because he has eliminated hpv been in my body since 2011, Dr. Onokun make it possible for me. Here is Dr. Onokun email: Dronokunherbalcure@gmail.com or page at:  https://www.facebook.com/naturaltreatmentcenter1 or WhatsApp him via +1 ( 323 ) 689 3594 and Website: Dronokunherbalcure.wordpress.com   he is welled capable of curing terrible diseases.  

    ReplyDelete

Post a Comment

Popular Posts