Quashing the resistance.
Ever wonder why HPV-associated squamous cell carcinomas of the anus and the head and neck are so much more radiosensitive than those of the cervix? Wonder no more. This excellent review touches on several evidence-based theories including differences in how HPV integrates itself into the local ecosystem and variations in the tumor microenvironment. For instance, cervical cancers have uniquely high levels of HPV E6/E7 expression with known associations with local immune evasion. While efforts thus far to overcome the radioresistance of cervical cancer have largely focused on safe delivery of dose-escalation, more out-of-the-box strategies include identifying molecular targets to diminish inherent tumor radioresistance and immunosuppression. | Beaty, Semin Radiat Oncol 2021