BED-side manner.

Top Line: What factors are associated with better local control of colorectal cancer lung oligometastases treated with SBRT?

The Study: We recently saw in the phase 2 SAFRON II trial that single fraction SBRT to 1-3 lung oligometastases was comparable to multifraction SBRT at least a 1 year. However, a post-hoc analysis found that many of the recurrences in the single fraction arm were colorectal primaries. Other studies have also demonstrated lower control rates of colorectal cancer oligometastases. LaIT-SABR was a large, multicenter retrospective study from Italy of > 500 patients treated with SBRT for >1000 colorectal cancer lung oligometastases. Most (57%) had colon primaries and 43% had rectal primaries. Median BED10 was 105 Gy with 31% receiving < 100 Gy, 56% 100-124 Gy, and 13% > 124 Gy. Overall, freedom from local progression (FLP) was 86% at 1 year and 75% at 2 years. FLP at 2 years was 94% for lesions that received 125+ Gy BED compared to 76% for lesions that received < 100 Gy BED and 71% for 100-124 Gy BED. On multivariable analysis, BED > 124 Gy and tumor diameter < 2 cm were associated with better FLP. In addition, the risk of poly-metastatic progression was higher for lesions > 2 cm, patients with 4-5 metachronous lesions, and those who received < 125 Gy BED.

TBL: Higher BED, smaller lesion size, and a smaller burden of disease are associated with better local control for colorectal cancer lung oligometastases treated with SBRT. | Nicosia, Radiother Oncol 2021


  1. Natural herbs can cure epilepsy, I had epilepsy for over 9 years, i have spent a lot money getting drugs from the hospital to keep me healthy, I went to many hospitals for cure but there was no solution, One day I was in the office going through the internet when I saw a post about Dr Sayo herbal medicine on how he cure a Lady from UK who was suffering from HIV and she listed Epilepsy as list of illness Dr Sayo can as well cured I contacted him with epilepsy Cure solution, I email him. He told me the things I need to do and also give me instructions on how to take the herbal cure, which I followed properly. Before I knew what is happening after 3 weeks To my greatest surprise after patiently going according to instruction given to me by Dr Sayo, my epilepsy was cure, I want to say a big thanks to Dr Sayo who God have sent to heal his people with his natural medicine I pray that God will bless you for the good work you are doing.for all who are still suffering from this illness, you can also contact him through his email on:;;  or whatsapp him +2349012175679 visit his website:  or visit his FB page: like they say his herbal remedy is the only permanent solution to Seizure. He Can as well cure the following... Herpes Virus, HIV/Aids, Hepatitis A/B, Shingles, Cold Sore, Epilepsy, Wart, Lupus, Diabetes, Men/Woman Infertility, Seizure, Cancer all types.


Post a Comment

Popular Posts