Top Line: Does metformin improve treatment outcomes for stage III NSCLC treated with chemoradiation?

The Studies: Two trials have recently been published exploring this question: OCOG-ALMERA and NRG-LU001. So, where did this idea come from? Population studies have linked metformin use with better survival and clinical outcome across several cancer types--including NSCLC. In preclinical studies, metformin has anti-proliferative effects on cancer cells via regulation of the AMPK pathway and inhibition of the mTOR pathway, and it may also be a radiosensitizer. Both ALMERA and LU001 were randomized phase 2 trials of definitive chemoradiation and consolidative chemo +/- metformin (no immunotherapy). LU001 was the larger of the two with 167 eligible patients whereas ALMERA was closed early with only 54 of a planned 96 patients enrolled. In both trials, the target metformin dose was 2000 mg per day. In LU001, the addition of metformin didn’t improve 1-year progression-free survival (51.3 vs 60.4%), overall survival (80.8 vs 80.2%), recurrence patterns, or adverse events. In ALMERA, 1-year PFS was significantly worse with metformin (34.8 vs 63%) and 1-year overall survival was 47.4 vs 85.2%. In addition, grade 3+ adverse events were higher with metformin (53.8 vs 25%).

TBL: Two randomized phase 2 studies show no evidence of improved treatment outcomes when metformin is added to chemoradiation for stage III NSCLC. | Skinner and Tsakiridis, JAMA Oncol 2021


  1. Hello to everyone out here, I am here to share the unexpected miracle that happened to me … My name is Susan Christian , I live in London, UK. we got married for more than 9 years and have gotten two kids. thing were going well with us and we are always happy. until one day my husband started to behave in a way i could not understand, i was very confused by the way he treat me and the kids. later that month he did not come home again and he called me that he want a divorce, i asked him what have i done wrong to deserve this from him, all he was saying is that he want a divorce that he hate me and do not want to see me again in his life, i was mad and also frustrated do not know what to do, i was sick for more than 2 weeks because of the divorce. i love him so much he was everything to me without him my life is incomplete. i told my sister and she told me to contact a spell caster, i never believe in all this spell casting of a thing. i just want to try if something will come out of it. i contacted Dr Emu for the return of my husband to me, they told me that my husband have been taken by another woman, that she cast a spell on him that is why he hate me and also want us to divorce. then they told me that they have to cast a spell on him that will make him return to me and the kids, they casted the spell and after 24 hours my husband called me and he told me that i should forgive him, he started to apologize on phone and said that he still love me that he did not know what happen to him that he left me. it was the spell that Dr Emu casted on him that make him come back to me today, me and my family are now happy again today. thank you Dr Emu for what you have done for me i would have been nothing today if not for your great spell. i want you my friends who are passing through all this kind of love problem of getting back their husband, wife , or ex boyfriend and girlfriend to contact Dr Emu , if you need his help you can contact him through his private mail: or you can contact him through his website fb page Https://


Post a Comment

Popular Posts