Age appropriate.

Top Line: More than 40% of patients diagnosed with esophageal cancer are 70 years or older.

The Study: Only a minority of this population can tolerate chemoradiation with standard platinum-based systemic therapy, with the default typically being radiation alone. Is there a better compromise? Enter S-1 again. This Chinese phase 3 trial enrolled 298 patients ages 70-85 receiving definitive radiation for locally advanced esophageal cancer with or without concurrent S-1. Radiation alone was prescribed to 60Gy/30 and chemoradiation was 54Gy/30 with S-1 prescribed 70 mg/m2 orally on days 1 to 14 and 29 to 42. In each group, radiation completion rate was 89-90%, and S-1 completion rate was 79%. Complete radiographic response was achieved in 27% after radiation alone and 42% after radiation with S-1. More impressive was the improvement in overall survival at 2 years from 36% → 53% with the addition of S-1. While there is a clear advantage in chemo completion among this older population with oral S-1 here as compared to an historical rate as low as 15% with intravenous agents, the authors also pose an interesting hypothesis that S-1 may actually be a superior radiosensitizer because the plasma half-life of fluorouracil during S-1 treatment is longer than when fluorouracil is intravenously administered.

TBL: The authors conclude oral S-1 concurrent to radiation should be the new standard for locally-advanced esophageal cancer among patients 70 or older, notwithstanding the fact it is not FDA-approved on this side of the globe. | Ji, JAMA Oncol 2021


  1. Hello to everyone out here, I am here to share the unexpected miracle that happened to me … My name is Susan Christian , I live in London, UK. we got married for more than 9 years and have gotten two kids. thing were going well with us and we are always happy. until one day my husband started to behave in a way i could not understand, i was very confused by the way he treat me and the kids. later that month he did not come home again and he called me that he want a divorce, i asked him what have i done wrong to deserve this from him, all he was saying is that he want a divorce that he hate me and do not want to see me again in his life, i was mad and also frustrated do not know what to do, i was sick for more than 2 weeks because of the divorce. i love him so much he was everything to me without him my life is incomplete. i told my sister and she told me to contact a spell caster, i never believe in all this spell casting of a thing. i just want to try if something will come out of it. i contacted Dr Emu for the return of my husband to me, they told me that my husband have been taken by another woman, that she cast a spell on him that is why he hate me and also want us to divorce. then they told me that they have to cast a spell on him that will make him return to me and the kids, they casted the spell and after 24 hours my husband called me and he told me that i should forgive him, he started to apologize on phone and said that he still love me that he did not know what happen to him that he left me. it was the spell that Dr Emu casted on him that make him come back to me today, me and my family are now happy again today. thank you Dr Emu for what you have done for me i would have been nothing today if not for your great spell. i want you my friends who are passing through all this kind of love problem of getting back their husband, wife , or ex boyfriend and girlfriend to contact Dr Emu , if you need his help you can contact him through his private mail: or you can contact him through his website fb page Https://


Post a Comment

Popular Posts