Fusion power.

Top Line: What molecular alterations drive different subtypes of rhabdomyosarcoma?

The Study: We’ve seen in many childhood malignancies that molecular categorization has important prognostic and predictive implications. Rhabdomyosarcoma, the most common soft tissue sarcoma in children, has been broadly categorized as embryonal or alveolar histology and then further subdivided upon clinicopathologic features. More recently, the presence or absence of FOXO1 fusion has been used for molecular risk stratification. Alveolar RMS is typically FOXO1 fusion positive (FP) whereas embryonal RMS is often fusion negative (FN) and driven by more diverse molecular alterations. Here is a genomic analysis of a large cohort of 614 patients treated on prospective, international cooperative group trials that attempts to shed light on the molecular landscape of RMS. Tumors were first categorized as FOXO1 fusion+ (FP) or fusion- (FN). Among FP tumors, the most common mutations involved CDK4 (13%) and MYCN (10%). FN tumors most commonly had mutations involving RAS isoforms (>50% total). However, 21% had no driver mutation at all. Instead, many of these tumors are driven by numerous genetic and chromosomal alterations. When it came to survival, TP53 mutation was predictive of worse outcome for both FP and FN tumors. In addition, MYOD1 mutation was also associated with poor outcomes among FN tumors.

TBL: An improved understanding of the molecular alterations that drive different subtypes of RMS will help develop future therapies and treatment paradigms for this diverse disease. | Shern, J Clin Oncol 2021


  1. Hello to everyone out here, I am here to share the unexpected miracle that happened to me … My name is Susan Christian , I live in London, UK. we got married for more than 9 years and have gotten two kids. thing were going well with us and we are always happy. until one day my husband started to behave in a way i could not understand, i was very confused by the way he treat me and the kids. later that month he did not come home again and he called me that he want a divorce, i asked him what have i done wrong to deserve this from him, all he was saying is that he want a divorce that he hate me and do not want to see me again in his life, i was mad and also frustrated do not know what to do, i was sick for more than 2 weeks because of the divorce. i love him so much he was everything to me without him my life is incomplete. i told my sister and she told me to contact a spell caster, i never believe in all this spell casting of a thing. i just want to try if something will come out of it. i contacted Dr Emu for the return of my husband to me, they told me that my husband have been taken by another woman, that she cast a spell on him that is why he hate me and also want us to divorce. then they told me that they have to cast a spell on him that will make him return to me and the kids, they casted the spell and after 24 hours my husband called me and he told me that i should forgive him, he started to apologize on phone and said that he still love me that he did not know what happen to him that he left me. it was the spell that Dr Emu casted on him that make him come back to me today, me and my family are now happy again today. thank you Dr Emu for what you have done for me i would have been nothing today if not for your great spell. i want you my friends who are passing through all this kind of love problem of getting back their husband, wife , or ex boyfriend and girlfriend to contact Dr Emu , if you need his help you can contact him through his private mail: emutemple@gmail.com or you can contact him through his website https://emutemple.wordpress.com/ fb page Https://web.facebook.com/Emu-Temple-104891335203341


Post a Comment

Popular Posts