Double VISION.

Top Line: The VISION trial was recently presented at ASCO 2021, and here is the full publication.

The Study: Prostate specific membrane antigen (PSMA) is over-expressed in many prostate cancer cells, which is associated with poor prognosis. In VISION, patients had castration-resistant prostate cancer with at least one visible metastasis on conventional imaging (mCRPC). They also had to have progressed after at least one prior androgen receptor pathway inhibitor and at least one prior taxane. Eligible patients underwent 68Ga-PSMA-11 PET/CT, and all radiographic metastases had to be PSMA-positive. Most clinically eligible patients (95%) were PSMA-positive, however 8.7% had at least one other PSMA-negative metastasis and they were ineligible for the trial. 831 patients were then randomized to receive standard of care therapy +/- Lu-177-PSMA-617. Importantly, standard therapies excluded cytotoxic chemo, other radioisotopes (Ra-223), or experimental agents. Of note, 56% of patients in the control arm withdrew during the first year of the trial prior to implementing measures to improve patient education. So, the final analysis includes 581 patients randomized after these measures. Lu-177-PSMA is a beta-emitter, and the dose was 7.4 GBq (200 mCi) every 6 weeks for 4 cycles (with the option of 2 additional cycles). As previously reported, Lu-177-PSMA improved imaging-based PFS (3.4→ 8.7 months) and overall survival (11.3→ 15.3 months). Imaging-PFS was defined by conventional imaging--not PSMA-PET. Side effects were higher with Lu-177-PSMA and mainly consisted of fatigue, dry mouth, and nausea. Ongoing trials are determining the benefit of Lu-177-PSMA as an earlier line of therapy.

TBL: The addition of Lu-177-PSMA-617 to standard therapy for PSMA-positive mCRPC progressing after an androgen receptor pathway inhibitor and a taxane significantly improves overall survival. | Sartor, N Engl J Med 2021

Comments

  1. Hello to everyone out here, I am here to share the unexpected miracle that happened to me … My name is Susan Christian , I live in London, UK. we got married for more than 9 years and have gotten two kids. thing were going well with us and we are always happy. until one day my husband started to behave in a way i could not understand, i was very confused by the way he treat me and the kids. later that month he did not come home again and he called me that he want a divorce, i asked him what have i done wrong to deserve this from him, all he was saying is that he want a divorce that he hate me and do not want to see me again in his life, i was mad and also frustrated do not know what to do, i was sick for more than 2 weeks because of the divorce. i love him so much he was everything to me without him my life is incomplete. i told my sister and she told me to contact a spell caster, i never believe in all this spell casting of a thing. i just want to try if something will come out of it. i contacted Dr Emu for the return of my husband to me, they told me that my husband have been taken by another woman, that she cast a spell on him that is why he hate me and also want us to divorce. then they told me that they have to cast a spell on him that will make him return to me and the kids, they casted the spell and after 24 hours my husband called me and he told me that i should forgive him, he started to apologize on phone and said that he still love me that he did not know what happen to him that he left me. it was the spell that Dr Emu casted on him that make him come back to me today, me and my family are now happy again today. thank you Dr Emu for what you have done for me i would have been nothing today if not for your great spell. i want you my friends who are passing through all this kind of love problem of getting back their husband, wife , or ex boyfriend and girlfriend to contact Dr Emu , if you need his help you can contact him through his private mail: emutemple@gmail.com or you can contact him through his website https://emutemple.wordpress.com/ fb page Https://web.facebook.com/Emu-Temple-104891335203341

    ReplyDelete

Post a Comment

Popular Posts