Making progress?

Top Line: Can serial MRI replace biopsy for men undergoing active surveillance for prostate cancer?

The Study: A practical challenge with active surveillance for prostate cancer is the need to perform serial biopsy to confirm disease status and rule out progression. Prostate biopsy is a key component of AS trials, so you can’t exactly expect the same outcomes while skipping out on the biopsy. That seems to be what happens in the real world, though. A population-based study from North Carolina recently showed that fewer than half of patients on AS have a repeat biopsy in the first 2 years and just 13% receive all guideline recommended surveillance tests. Have we reached a point where MRI could replace biopsy? This systematic review and meta-analysis evaluated the ability of serial MRI to detect progression during AS. It included 15 studies, 6 of which used the standardized PRECISE criteria for progression. Although MRI has become an effective diagnostic tool, it was not accurate enough when it came to detecting overall disease progression as it potentially missed 15-20% of disease progression. The pooled sensitivity, specificity, PPV, and NPV for progression were 0.59, 0.75, 0.5, and 0.85. However, MRI did seem effective at ruling out progression to grade group 3 (NPV 0.95)analogous to its diagnostic detection of clinically significant disease.

TBL: Many men on AS for prostate cancer don’t undergo guideline-recommended serial biopsy, and serial MRI is not yet accurate enough at predicting progression to replace biopsy. | Chen, Int J Radiat Oncol Biol Phys 2021 and Rajwa, Euro Urol 2021


  1. To know more about Chief Dr Lucky you can visit his website (
     A friend that suffered from Herpes and was cure with the help of this great herbal doctor Chief Lucky so i decided to contact him for help in getting rid of my families genital herpes virus 1/2 which i did and all i was told to provide was just some useful information and some materials used in preparation of the natural cure and that i did and now i am the happiest person on earth because i am writing this testimony of mine with joy and happiness in my heart to the whole world to know that natural remedy is real because i am a living testimony of Chief Lucky traditional herbal cure and i want you all to contact Chief Lucky via his email: or WhatsApp him +2348132777335 am sure he will help you too.

  2. The method of execution is really impressive of writers of this blog. This team does really work hard and brings new information to its readers. I am connected with this blog very long and I am really thankful kubet lua dao

  3. Hello to everyone out here, I am here to share the unexpected miracle that happened to me … My name is Susan Christian , I live in London, UK. we got married for more than 9 years and have gotten two kids. thing were going well with us and we are always happy. until one day my husband started to behave in a way i could not understand, i was very confused by the way he treat me and the kids. later that month he did not come home again and he called me that he want a divorce, i asked him what have i done wrong to deserve this from him, all he was saying is that he want a divorce that he hate me and do not want to see me again in his life, i was mad and also frustrated do not know what to do, i was sick for more than 2 weeks because of the divorce. i love him so much he was everything to me without him my life is incomplete. i told my sister and she told me to contact a spell caster, i never believe in all this spell casting of a thing. i just want to try if something will come out of it. i contacted Dr Emu for the return of my husband to me, they told me that my husband have been taken by another woman, that she cast a spell on him that is why he hate me and also want us to divorce. then they told me that they have to cast a spell on him that will make him return to me and the kids, they casted the spell and after 24 hours my husband called me and he told me that i should forgive him, he started to apologize on phone and said that he still love me that he did not know what happen to him that he left me. it was the spell that Dr Emu casted on him that make him come back to me today, me and my family are now happy again today. thank you Dr Emu for what you have done for me i would have been nothing today if not for your great spell. i want you my friends who are passing through all this kind of love problem of getting back their husband, wife , or ex boyfriend and girlfriend to contact Dr Emu , if you need his help you can contact him through his private mail: or you can contact him through his website fb page Https://


Post a Comment

Popular Posts