An apal a day.

Top Line: Anyone not confused on the best systemic therapy for metastatic castrate-sensitive prostate cancer? 

The Study: Like enzalutamide, apalutamide threw it’s hat in the ring with initial reporting of the phase 3 TITAN trial at ASCO 2019 by demonstrating an improvement in survival when compared to first-generation androgen deprivation therapy (ADT) alone. We now have the final survival analysis here to cement apalutamide as a serious contender for first-line status. Among over 1000 men, the addition of apalutamide to ADT significantly reduced the risk of death by 35%—median overall survival was just over 4 years in the ADT alone arm and not yet reached in the apalutamide arm. The kicker is, when adjusting for crossover which was allowed, the risk of death was actually slashed in half in those receiving apalutamide. What’s more, the addition of apalutamide didn’t result in an additional dip in health-related quality of life. Now the real question is how this all stacks up against other ADT intensification strategies such as docetaxel or abiraterone. Absent a head-to-head comparison, the authors conclude the benefit of apalutamide is all in the side effects, or lack thereof.

TBL: Apalutamide significantly improves survival when added to ADT across a broad population of men with metastatic castrate sensitive prostate cancer and, along with its cousin enzalutamide, provides the only chemo- and steroid-free option for ADT intensification. | Chi, J Clin Oncol 2021

Comments

  1. To know more about Chief Dr Lucky you can visit his website (https://chiefdrluckyherbaltherapy.wordpress.com/)
     
     A friend that suffered from Herpes and was cure with the help of this great herbal doctor Chief Lucky so i decided to contact him for help in getting rid of my families genital herpes virus 1/2 which i did and all i was told to provide was just some useful information and some materials used in preparation of the natural cure and that i did and now i am the happiest person on earth because i am writing this testimony of mine with joy and happiness in my heart to the whole world to know that natural remedy is real because i am a living testimony of Chief Lucky traditional herbal cure and i want you all to contact Chief Lucky via his email: chiefdrlucky@gmail.com or WhatsApp him +2348132777335 am sure he will help you too.

    ReplyDelete
  2. The method of execution is really impressive of writers of this blog. This team does really work hard and brings new information to its readers. I am connected with this blog very long and I am really thankful kubet lua dao

    ReplyDelete

Post a Comment

Popular Posts