Risky business.

Top Line: CDK 4/6 inhibitors play an important role in the treatment of advanced, hormone receptor positive, HER2- breast cancer.

The Study: Several trials are also asking whether women with localized breast cancer may also benefit from adjuvant CDK 4/6 inhibition. Recently, the monarchE trial found that 2 years of abemaciclib improved 3-year invasive disease-free survival (iDFS) by 3.5% (88.7 → 92.2%) in women with high risk (mostly LN+) hormone receptor (HR)+ breast cancer. However, the PALLAS trial found no improvement in 3-year iDFS with 2 years of palbociclib (88.2% vs 88.5%). The PENELOPE-B trial sought to determine if 1 year of adjuvant palbociclib could improve iDFS specifically among patients who have high risk, HR+/HER2- residual disease following neoadjuvant chemotherapy. 1250 patients were randomized to standard endocrine therapy +/- 1 year of palbociclib. “High risk of relapse” was defined as a score of ≥3 or a score of 2 and ypN+ using the clinical pathological staging-estrogen receptor grading (CPS-EG) scoring system. There was no significant difference in rate of iDFS at 3 years at 81.2% with palbociclib and 77.7% with placebo. And you’d be correct in noting that the 3.5% difference wasn’t significant in PENELOPE-B, although it enrolled less than a quarter the number of patients in monarchE. You do the math.

TBL: While there may be a benefit from the addition of CDK 4/6 inhibition among select women with high risk localized HR+ breast cancer, ideal patient selection remains elusive. | Loibl, J Clin Oncol 2021


  1. To know more about Chief Dr Lucky you can visit his website (https://chiefdrluckyherbaltherapy.wordpress.com/)
     A friend that suffered from Herpes and was cure with the help of this great herbal doctor Chief Lucky so i decided to contact him for help in getting rid of my families genital herpes virus 1/2 which i did and all i was told to provide was just some useful information and some materials used in preparation of the natural cure and that i did and now i am the happiest person on earth because i am writing this testimony of mine with joy and happiness in my heart to the whole world to know that natural remedy is real because i am a living testimony of Chief Lucky traditional herbal cure and i want you all to contact Chief Lucky via his email: chiefdrlucky@gmail.com or WhatsApp him +2348132777335 am sure he will help you too.

  2. The method of execution is really impressive of writers of this blog. This team does really work hard and brings new information to its readers. I am connected with this blog very long and I am really thankful kubet lua dao


Post a Comment

Popular Posts