In isolation.

With increasing abilities to detect even a few cells of endometrial cancer spread to nearby pelvic lymph nodes, what are we supposed to do with that?? Here’s a multi-institutional retrospective look at 175 women with isolated tumor cells (i.e., <200 cells and < 0.2 mm) only noted in sentinel lymph node samples at time of hysterectomy for endometrial cancer. At a median follow-up of 2.5 years, only 9 (5%) recurred. On multivariate analysis, post-op receipt of neither chemo (n=78) nor external beam radiation (n=21) made any difference on recurrence as compared to those getting neither (n=76). While not definitive, this data suggests, analogous to breast cancer, isolated tumor cells should not impact treatment recommendations. | Backes, Gynecol Oncol 2021

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