CODEL origins.

Top Line: The CODEL trial was originally designed to determine if radiation alone, radiation + temozolomide, or temozolomide alone was the best treatment for WHO grade III 1p19q codeleted oligodendroglioma.

The Study: However, it underwent major revisions after initiation. When the long-term results of RTOG 9402 and EORTC 26951 showed major improvement in survival (especially with 1q/19q codeletion) when PCV was added to radiation, the radiation alone arm was converted to radiation + PCV. The TMZ alone arm was also dropped after initial results suggested inferior outcomes compared to radiation arms. Thus, CODEL is now a comparison of radiation + TMZ and radiation + PCV. This report describes outcomes for the 36 patients enrolled in the original study design. Obviously, these results are not adequately powered, but they provide an insightful comparison of treatment approaches that were common at the time. After median follow-up of > 7 years, 83% of TMZ alone patients had disease progression compared to just 37.5% in the radiation arms. At the 5 year mark, progression-free survival was 33% with TMZ versus 56% with radiation. It cleary wasn't powered to detect a significant difference, but the discrepancy in overall survival at 5 years was noteworthy at 67% after TMZ alone versus 91% with radiation. Lastly, there was no difference in the rate of cognitive decline 3 months after treatment (67% versus 75%, respectively).

TBL: “Treatment with TMZ alone of newly diagnosed patients with 1p/19q codeleted WHO grade III oligodendroglial tumors was associated with significantly inferior progression-free survival compared with radiation.” | Jaeckle, Neuro Oncol 2021


  1. To know more about Chief Dr Lucky you can visit his website (
     A friend that suffered from Herpes and was cure with the help of this great herbal doctor Chief Lucky so i decided to contact him for help in getting rid of my families genital herpes virus 1/2 which i did and all i was told to provide was just some useful information and some materials used in preparation of the natural cure and that i did and now i am the happiest person on earth because i am writing this testimony of mine with joy and happiness in my heart to the whole world to know that natural remedy is real because i am a living testimony of Chief Lucky traditional herbal cure and i want you all to contact Chief Lucky via his email: or WhatsApp him +2348132777335 am sure he will help you too.

  2. The method of execution is really impressive of writers of this blog. This team does really work hard and brings new information to its readers. I am connected with this blog very long and I am really thankful kubet lua dao


Post a Comment

Popular Posts