All in good time.
We’re still not sure of the best timing to implement oliGomez data into immune checkpoint inhibition (ICI). At what point after diagnosis of oligomets should SBRT happen when indefinite ICI is planned? This preclinical data suggests timing does matter. When mice received ICI initiated either 2 days prior or 2 days after a single 8 Gy x 1 treatment to colon carcinoma tumors, expansion of anti-tumor CD8+ tumor cells and systemic tumor response was significantly boosted when ICI came directly after radiation. | Wei, Sci Immunol 2021