No small matter.

Top Line: Is there a brain dose constraint comparable to the V12 for patients receiving 5-fraction SRS for brain metastases?

The Study: Brain V12 is a frequently used normal tissue constraint that is associated with radiation necrosis risk after single fraction SRS. It can be challenging to extrapolate the single fraction V12 metric for fractionated SRS. And while plan quality metrics like conformity and gradient should really drive SRS planning, some like to have normal tissue constraints to assess the risk of toxicity. In this multi-institutional retrospective study of >80 patients receiving 5-fraction SRS (mostly 30 Gy), brain V25 > 16 cc and V30 > 10 cc were associated with a significant increase in the risk of symptomatic radiation necrosis. More specifically, it was the volume of uninvolved brain (i.e. outside the target) that was associated with necrosis risk, and that risk went from 2% to >20% when both thresholds were exceeded. Such thresholds may be good indicators of the overall risk of necrosis and could also influence the choice of prescription dose.

TBL: Uninvolved brain V25 and V30 may be good measures of necrosis risk after 5-fractions SRS for brain metastases. | Andruska, Radiother Oncol 2020

Comments

  1. To know more about Chief Dr Lucky you can visit his website (https://chiefdrluckyherbaltherapy.wordpress.com/)
     
     A friend that suffered from Herpes and was cure with the help of this great herbal doctor Chief Lucky so i decided to contact him for help in getting rid of my families genital herpes virus 1/2 which i did and all i was told to provide was just some useful information and some materials used in preparation of the natural cure and that i did and now i am the happiest person on earth because i am writing this testimony of mine with joy and happiness in my heart to the whole world to know that natural remedy is real because i am a living testimony of Chief Lucky traditional herbal cure and i want you all to contact Chief Lucky via his email: chiefdrlucky@gmail.com or WhatsApp him +2348132777335 am sure he will help you too.

    ReplyDelete
  2. This is such a great resource that you are providing and you give it away for free. I love seeing blog that understand the value of providing a quality resource for free kubet

    ReplyDelete

Post a Comment

Popular Posts