On your 6.

Top Line: Is ultra-hypofractionated whole bladder radiation an effective option for patients with muscle invasive bladder cancer who aren’t candidates for standard treatment?

The Study: Many patients with non-metastatic MIBC are not candidates for either radical surgery or chemoradiation. Yet, their localized disease may warrant more than strictly palliative treatment (or no treatment at all). The HYBRID Trial evaluated the efficacy of an ultra-hypofractionated regimen for treatment of 65 patients with node-negative MIBC who weren’t candidates for standard therapy. All patients were treated with 36 Gy in 6 once-weekly fractions to the whole bladder. The trial was a randomized, non-comparative phase 2 design that compared standard planning with adaptive planning. All patients were simulated with an empty bladder. The CTV consisted of the bladder (and tumor) and proximal urethra. In the standard arm, a single plan was generated using a 1.5 cm symmetric expansion. In the adaptive arm, three separate plans were generated using three (small, medium, and large) asymmetric PTV expansions. At 3 months, local control was >80% and at 1 year >80% were still free from invasive recurrence. Non-GU grade 3+ toxicity was favorable in both arms (13% standard tx, 6% adaptive tx). The utilization of adaptive plans (39%) exceeded a threshold (25%) that suggests such an approach may provide a clinically meaningful benefit.

Bottom Line: 36 Gy in 6 fractions (+/- adaptive planning) appears tolerable and effective for patients with localized MIBC who aren’t candidates for standard therapy. | Huddard, Int J Radiat Oncol Biol Phys 2020

Comments

  1. HERBAL DR EMU WHO PREPARE HERBAL MEDICINE TO CURE ALL KINDS OF DISEASES INCLUDING HERPES DISEASE.   
     I have been battling this Herpes disease for almost 3 years now....I tried all possible means to get cure from my Herpes Disease but all to be in vain until i saw a post in a health forum about a herbal Dr Emu who prepare herbal medicine to cure all kind of diseases including Herpes Disease, at first i doubted if it was real but decided to give it a try...when i contact Dr Emu via his email (emutemple@gmail.com)  write him and reply me explain how the process work so after ordering for the medicine I got it within 3/4 working days through DHL Delivery and I took it according to the way Dr Emu instructed, I was so happy after 2 week I took the medicine there was very big change in my health when I was done with the process I go for test, I found out I am negative...Herpes patients should also get in touch with this herbalist Dr Emu to get rid of these Herpes Virus forever his whatsapp number +2347012841542.

    ReplyDelete

Post a Comment

Popular Posts