Haiku.

Top Line: Is there a benefit to peri-operative aromatase inhibitor (POAI) therapy for women with early stage, hormone receptor positive breast cancer?

The Study: There are two parts to this question. First, does POAI improve clinical outcomes? Given that these treatments are given for 5-10 years, you can guess the answer to that question. Another question is whether the response to a short course of POAI can be used to direct subsequent therapy. You’re probably thinking, “don’t we use genomic classifiers for that.” Yes, but as we learned recently, those tests can be heterogeneous in how they predict the benefit of adjuvant therapy, and some might argue they’re “expensive” and not universally available. POETIC was a large UK trial that randomized nearly 4500 post-menopausal women with early stage, ER+ breast cancer to standard therapy with or without POAI. Ki67 was used as a biomarker of proliferation and assessed before and after 2 weeks of POAI. In this report of long-term outcomes, there was no difference in any clinical outcome with or without POAI therapy. From a prognostic standpoint, though, the change in Ki67 with short-course POAI was associated with the risk of recurrence. At 5 years, recurrence risk was 4.3% for those with initially low Ki67, 8.4% for high→ low, and 21.5% for high→ high. Unfortunately, actual adjuvant systemic therapy was not dictated by response in this trial.

TBL: Change in Ki67 after a short course of POAI is prognostic of recurrence risk among post-menopausal women with hormone receptor positive breast cancer. | Smith, Lancet Oncol 2020

Comments

  1. HERBAL DR EMU WHO PREPARE HERBAL MEDICINE TO CURE ALL KINDS OF DISEASES INCLUDING HERPES DISEASE.   
     I have been battling this Herpes disease for almost 3 years now....I tried all possible means to get cure from my Herpes Disease but all to be in vain until i saw a post in a health forum about a herbal Dr Emu who prepare herbal medicine to cure all kind of diseases including Herpes Disease, at first i doubted if it was real but decided to give it a try...when i contact Dr Emu via his email (emutemple@gmail.com)  write him and reply me explain how the process work so after ordering for the medicine I got it within 3/4 working days through DHL Delivery and I took it according to the way Dr Emu instructed, I was so happy after 2 week I took the medicine there was very big change in my health when I was done with the process I go for test, I found out I am negative...Herpes patients should also get in touch with this herbalist Dr Emu to get rid of these Herpes Virus forever his whatsapp number +2347012841542.

    ReplyDelete
  2. This is such a great resource that you are providing and you give it away for free. I love seeing blog that understand the value of providing a quality resource for free kubet

    ReplyDelete

Post a Comment

Popular Posts