Pure gold.

This basic science work reports that glioblastoma (GBM) cells with higher levels of purines—a common result of a variety of GBM-related pathogenic mutations—have greater radioresistance due to an increased ability to repair DNA damage. This sparked a demonstration that administration of the already FDA-approved mycophenolate mofetil, a purine biosynthesis blocker, led to increased radiosensitivity in GBM murine models. | Zhou, Nature Commun 2020


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