I want it theta way.

Cells with deficiencies in homologous recombination (e.g. BRCA-mutations), rely heavily on other, more error-prone, methods of DNA repair such as the one mediated by polymerase theta (Pol ϴ). Novel targeted CRISPR screening revealed 140 additional genes that, when lost, also make a cell heavily reliant on (aka “addicted to”) this error prone Pol ϴ pathway. Not only that, 30% of breast cancers in The Cancer Genome Atlas harbored these Pol ϴ-addicted genes. In other words, Pol ϴ inhibition may be the new PARP inhibition. | Feng, Nat Commun 2019


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