10-4, 1016.

As we heard at ASTRO 2018, and in line with De-ESCALaTE, the full pub describing RTOG 1016 indicates cetuximab produces inferior survival and no less toxicity compared to cisplatin when delivered concurrent with definitive radiation. In contrast to De-ESCALaTE, 1016 was a noninferiority trial with a primary outcome of overall survival at 5 years. Here again that outcome was worse with cetuximab (78%) than with cisplatin (85%). And, again, this was driven by recurrences: Locoregional recurrence at 5 years was 17% with cetuximab and 10% with cisplatin. Message received. Gillison, Lancet 2018 (cetuximab saga part 2/2)


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