Meet the new boss, same as the old boss.

Headline: Cetuximab can’t replace standard platinum chemo concurrent to definitive radiation for p16(+) oropharyngeal squamous cell carcinoma (SCC).
The Study: You’re already familiar with the rationale for this study so let’s dive right into the presented results (LBA4). This first analysis includes 805 patients (90% male) receiving definitive conventionally-fractionated radiation delivered 6 days per week. They were randomized to concurrent q3 weekly cisplatin 100 mg/m2 x 2 versus weekly cetuximab x 8 with a primary endpoint of overall survival. Unfortunately, the hazard ratio for death with cetuximab perfectly straddled the maximum upper limit predefined to achieve “non-inferiority” (HR 1.45). What’s more, it was significantly worse, as was risk of death or progression (HR 1.72). These provocative results are further bolstered by those reported this week at ESMO on the similarly designed De-ESCALaTE HPV trial.
Bottom Line: After all this we can now proclaim the new boss of systemic therapy in this setting is...same as the old boss, serving you faithfully since 1971. | Trotti, ASTRO 2018


  1. i want to say a very big thanks to Dr Aluya for helping me return my boyfriend home with his powerful spell i never believe my boyfriend will come back to me after Eight months of breaking up with me i decided to go online to search for a powerful spell caster i met a lot of testimony online about Dr Aluya so i decided to give him a try and i contacted him for help and he give me his words not to worry about anything once He is done with his work after 48hrs my boyfriend is going to be back,after 48hrs i receive a phone call when i pick it i hard my boyfriend voice and he started pleading with me to forgive him  which i did for more info you can contact his Email you can also add him up on whatsapp +2348110493039 may God continue to bless your hand work.


Post a Comment

Popular Posts