Sleeping in.

If you like to include surgeons in your radiosurgeries, chances are they're being scheduled at the butt crack of dawn. This study shows circadian variation plays a big role in cardiac stress response and injury following open heart surgery. In short, high Rev-Erb𝝰 gene expression in the early morning hours suppresses CDKN1a (aka p21) that is responsible for cell damage response, meaning early surgeries may lead to harder recoveries. We bet such circadian fluctuations also play some role in tumor and normal tissue response to radiation damage. Just something to consider when you schedule your next sunrise radiosurgery. | Montaigne, Lancet 2017


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