Some scientific breakthroughs happen by chance. All scientific breakthroughs happen when a dedicated scientist takes note. Trust us, this incredible story of CAR-T cell development is worth your read. Including the part about, when the first child to ever receive CAR-T cells was approaching the brink of death, her physician noted extremely high IL-6 levels. Then he thought to himself, huh, my daughter was just prescribed tocilizumab (anti-IL-6R) for juvenile rheumatoid arthritis--so let’s try it. In that moment he saved not only his patient’s life but also the future of CAR-T cells by effectively treating the first cytokine release syndrome before anyone knew what it was. TBL: What chance happenings are you going to notice today?