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It’s not the same as clinically significant. Recent research is boldly asking how many of the statistically significant results of recent immunotherapy trials are actually, well, significant. Since this is not a novel question for Europeans, long standing ESMO standards were used to novely assess >100 randomized trials founding the bases for US FDA-approved oncology drugs over the last decade. In doing so, international (non-US) researchers reported less than half of these trial results met a clinically meaningful threshold. To top it off, last week Israeli researchers reported that only 3 of 23 recently US FDA-approved indications across six immunotherapies met a clinically significant durable survival benefit as defined by none other than ASCO itself. This all brings up two concerns: Resource. Utilization.