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June 29, 2017. The linear-quadratic (LQ) model doesn't work outside a narrow range of standard fraction sizes. Using a mechanistic model of cell growth and radiation effects (as opposed to empiric LQ model), this study in Clinical Cancer Research evaluated various radiation regimens for non-small cell lung cancer (NSCLC). Stereotactic body radiation (SBRT) doses are effective by overcoming most of the ways cancer cells resist radiation (hypoxia, proliferation, repopulation) whereas standard doses lose their effectiveness largely due to repopulation. This model should be better at predicting dose responses, but there is still a lot to figure out. Stay tuned.