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Olivia Newton-John revealed she has recurrent, metastatic breast cancer after original diagnosis in 1992. After 25 years, she developed bone mets to the sacrum causing back pain earlier this year. Though we don't know the details of her diagnosis, her doctors should probably familiarize themselves with PALOMA-2 that demonstrated a significant survival improvement with the CDK4/6 inhibitor palbociclib (Ibrance) and letrozole in metastatic hormone-receptor(+) breast cancer. Now that's a tune we can Ibrance to.