Skip to main content

Posts

Featured

Power outages.

Top Line : Do patients with sentinel lymph node positive breast cancer benefit from regional nodal irradiation? The Study : Sure, there are a number of trials addressing this topic, but many were plagued by lower than planned accrual. Here’s another to add to the list. OPTIMAL was a randomized, phase 3 trial from Spain and Portugal designed to test the non-inferiority of whole breast radiation alone in patients with clinically occult node-positive disease after breast conservation surgery and sentinel lymph node biopsy (SLNB). Eligible patients had cT1-2N0 invasive ductal carcinoma and occult lymph node metastasis after breast conservation surgery and SLNB. Most (95%) had ER+ disease. Here’s where the trial took a small detour. Instead of quantifying SLNB nodal burden by counting the number of positive nodes, nodal burden was quantified by CK19 expression. One-step nucleic acid amplification (OSNA) measured the expression of CK19 and calculated a total tumor load (TTL), which is the

Latest Posts

Room for a positive.

Control.

Node positive.

Now you see it.

Long time coming.

A PIRADS life.

Treatment-free survival.

Damage control.

Count on it.

Introspection.

Persistence.

Necrosis for the mostest.

Risky business.

Minimalist.

Still abscoping it out.

LASRE focus.

Lifetime movie.

Eye of the beholder.