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More APBI outcomes.

Top Line : Are local control outcomes with interstitial brachytherapy ABPI comparable to whole breast radiation? The Study : There are multiple techniques for delivering accelerated partial breast irradiation. Randomized trials of various APBI techniques have had mixed results with respect to local control and cosmesis. Here we have 10-year outcomes from the GEC-ESTRO trial comparing exclusive interstitial brachytherapy APBI and whole breast radiation. 1184 patients eligible for analysis had ≤3 cm tumors with ≤pNmi disease, no LVI, and at least 2 mm margins (5mm for any DCIS). In the WBRT arm, everyone received 50-50.4 Gy in 25-28 fractions with a 10 Gy in 5 fractions boost. In the APBI arm, the CTV was defined on pre- and post-implant CT and consisted of the tumor bed with at least a 2 cm margin. Both HDR and pulsed-dose-rate brachytherapy were used. For HDR, the prescription was either 32 Gy in 8 BID fractions or 30.1 Gy in 7 BID fractions. For PDR, the prescription was 50 Gy give

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